The COVID-19 crisis defies conventional approach to tackling international crises and trigger policy responses globally. Notwithstanding, it is expected that policies should conform to International legal standards on human rights of migrants (ILSHRMs) treatment and protection, but it seems COVID-19 policy responses (CPRs) in China and United States of American (CUSA) are undermining African-Black migrants’ rights. Extant researches with concentrations on human rights dimension of COVID-19 responses do not adequately investigate on African-Black migrants’ rights, combining countries cases this current research addresses. This study investigates whether CPRs in CUSA are undermining human rights of African-Black migrants and the implications for Africa-CUSA relations. Using qualitative technique, it reveals among others, that, even though ILSHRMs treatment and protection, prohibits discrimination and guarantee to all person: equal access, treatment and effective protection against discrimination and stigmatization irrespective of social identity, CPRs in CUSA have viciously undermined the human rights of African-Black migrants to: equal access, treatment and protection; Therefore, this study identifies and predicts three conflict-implications and concludes that continuous underminization of the human rights of African-Black migrants would portray CUSA humanitarian assistance in Africa as diplomatic hypocrisy and requires proper intervention to stop the menace and to avoid the conflict-implications for Africa-CUSA relations.